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Likewise, magnesium deficit has impaired cellular and humoral immune function, delaying the sequential inflammatory response

van Gisbergen MW, Cebula M, Zhang J, Ottosson-Wadlund A, Dubois L, Lambin P, et al

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After binding to the IL-1 type I receptor, IL-1 could mediate the activation of the HPA axis in the rodent model of depression (79), which provides evidence for IL-1s role in activating the HPA axis